We ship every order in plain, discreet packaging, without any branding or labels. You don’t need health insurance or an existing prescription to use our service. Our clinicians will issue a free private prescription if you’re eligible for treatment. After you’ve filled out the online consultation, you’ll be able to choose from recommended treatments for erectile dysfunction.You’ll have the option to make a one-time purchase, or start a subscription.If you subscribe we’ll automatically refill your treatment so you don’t run out, without the need to regularly complete a consultation or checkout. You can cancel subscription online at anytime. Order in6 hrs 4 minsfor delivery by tomorrow All content on this page has been medically reviewed by: Hassan Thwaini, Clinical Pharmacist and Copywriter, Master of Pharmacy (MPharm) on 30 March, 2026. Tadalafil is a clinically-proven erectile dysfunction treatment that gives you the freedom to enjoy sex when you want it.
Other Uses for ED Medications
Either increases effects of the other by pharmacodynamic synergism. Coadministration of vericiguat with PDE-5 inhibitors may result in additive hypotensive effects. apalutamideapalutamide will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Coadministration of apalutamide, a strong CYP3A4 inducer, with drugs that are CYP3A4 substrates can result in lower exposure to these medications. Avoid or substitute another drug for these medications when possible.
The Bottom Line
Evaluate for loss of therapeutic effect if medication must be coadministered. Adjust dose according to prescribing information if needed. apalutamide will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. atazanaviratazanavir will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stop tadalafil >24 hours prior to protease inhibitor (PI) initiation, restart 7 days after PI initiation at 20 mg once daily, and increase to 40 mg once daily based on tolerability. It lasts for 36 hours - so there’s less need for planning before sex. Find the clinically proven ED treatment that suits you best. No names, no logos, no delivery fee. 4.6* from over 33,000 people like you. BSc (Hons) MBBS MRCGP AFHEA MA (Hons) AFMCP Answer a few simple questions to get the treatment you need. Indicated for treatment of erectile dysfunction (ED) Cialis (or generic equivalent) or Chewtadzy only PRN use: 10 mg PO initially before sexual activity, with or without food; may be increased to 20 mg or reduced to 5 mg on basis of efficacy and tolerability; in most patients, maximum dosing frequency is once daily Once-daily use (Cialis): 2.5 mg/day PO in single daily dose, without regard to timing of sexual activity, with or without food; may be increased to 5 mg/day on basis of efficacy and tolerability Indicated for treatment of signs and symptoms of benign prostatic hyperplasia (BPH); daily use also indicated for treatment of patients with both BPH and erectile dysfunction Cialis (or generic equivalent) or Chewtadzy only BPH with ED: 5 mg PO once daily, taken at approximately same time each day without regard to timing of sexual activity Coadministration with finasteride for BPH: Tadalafil 5 mg plus finasteride 5 mg PO once daily for ≤26 weeks; incremental benefit of tadalafil decreases from 4 weeks until 26 weeks, and the benefit beyond 26 weeks is unknown Indicated for pulmonary arterial hypertension (PAH) (WHO Group 1) to improve exercise ability; studies establishing effectiveness included predominately patients with NYHA Functional Class II – III symptoms and etiologies of idiopathic or heritable PAH (61%) or PAH associated with connective tissue diseases (23%) Adcirca, Alyq, Tadliq, or generic equivalent only 40 mg PO once daily; dividing dose for more frequent dosing is not recommended Patients also taking ritonavir: 20 mg PO once daily initially for ≥1 week; may be increased to 40 mg/day on basis of tolerability Cialis, Chewtadzy (PRN use)Mild (CrCl >50 mL/min): No dosage adjustment neededModerate (CrCl 30-50 mL/min): Not to exceed 5 mg PO once daily initially; maximum dosage, 10 mg PO q48hrSevere (CrCl <30 mL/min and on hemodialysis): Not to exceed 5 mg PO q72hr Mild (CrCl >50 mL/min): No dosage adjustment needed Moderate (CrCl 30-50 mL/min): Not to exceed 5 mg PO once daily initially; maximum dosage, 10 mg PO q48hr Severe (CrCl <30 mL/min and on hemodialysis): Not to exceed 5 mg PO q72hr Cialis (once daily use)ED (CrCl >50 mL/min): No dosage adjustment neededBPH or BPH/ED (CrCl 30-50 mL/min): 2.5 mg/day starting dose recommended; may increase to 5 mg according to individual responseED or BPH (CrCl <30 mL/min or hemodialysis): Not recommended ED (CrCl >50 mL/min): No dosage adjustment needed BPH or BPH/ED (CrCl 30-50 mL/min): 2.5 mg/day starting dose recommended; may increase to 5 mg according to individual response ED or BPH (CrCl <30 mL/min or hemodialysis): Not recommended Chewtadzy (once daily use)BPH, ED/BPHCrCl >50 mL/min: No dosage adjustment neededCrCl ≤50 mL/min or hemodialysis: Not recommended CrCl >50 mL/min: No dosage adjustment needed CrCl ≤50 mL/min or hemodialysis: Not recommended Adcirca, Alyq, TadliqMild-to-moderate (CrCl 31-80 mL/min): 20 mg PO once daily initially; may be increased to 40 mg once daily on basis of tolerabilitySevere (CrCl <30 mL/min and on hemodialysis): Avoid use Mild-to-moderate (CrCl 31-80 mL/min): 20 mg PO once daily initially; may be increased to 40 mg once daily on basis of tolerability Severe (CrCl <30 mL/min and on hemodialysis): Avoid use Cialis, Chewtadzy (PRN use)Mild-to-moderate (Child-Pugh class A or B): Not to exceed 10 mg PO once dailySevere (Child-Pugh class C): Not recommended Mild-to-moderate (Child-Pugh class A or B): Not to exceed 10 mg PO once daily Severe (Child-Pugh class C): Not recommended Cialis, Chewtadzy (once daily use)Mild-to-moderate (Child-Pugh class A or B): Data limited; caution advisedSevere (Child-Pugh class C): Not recommended Mild-to-moderate (Child-Pugh class A or B): Data limited; caution advised Severe (Child-Pugh class C): Not recommended Adcirca, Alyq, TadliqMild-to-moderate (Child-Pugh class A or B): Consider starting dosage of 20 mg PO once dailySevere (Child-Pugh class C): Avoid use Mild-to-moderate (Child-Pugh class A or B): Consider starting dosage of 20 mg PO once daily Severe (Child-Pugh class C): Avoid use ED PRN use: Not to exceed 10 mg/72 hr ED or ED/BPH once-daily use: Not to exceed 2.5 mg/day Adcirca, Alyq, TadliqOn ritonavir for at least 1 week: Start tadalafil at 20 mg PO qDay; may increase to 40 qDay based on individual tolerabilityAvoid tadalafil during ritonavir initiationStop tadalafil at least 24 hr before to starting ritonavirAfter at least 1 week following ritonavir initiation, resume tadalafil 20 mg PO qDay; may increase to 40 qDay based on individual tolerability On ritonavir for at least 1 week: Start tadalafil at 20 mg PO qDay; may increase to 40 qDay based on individual tolerability Stop tadalafil at least 24 hr before to starting ritonavir After at least 1 week following ritonavir initiation, resume tadalafil 20 mg PO qDay; may increase to 40 qDay based on individual tolerability Chewtadzy: Not indicated for once daily use for ED because dosing is not possible (recommended dosage for this indication cannot be achieved with lowest available strength) Orphan designation for Duchenne muscular dystrophy (DMD) Eli Lilly and Company; Lilly Corporate Center; Indianapolis, IN 46285 Indicated for treatment of erectile dysfunction (ED) Cialis or generic equivalent only: No dosage adjustment is warranted solely on basis of age; however, greater sensitivity to medications in some older individuals should be considered Indicated for pulmonary arterial hypertension (PAH) (WHO Group 1) to improve exercise ability; studies establishing effectiveness included predominately patients with NYHA Functional Class II – III symptoms and etiologies of idiopathic or heritable PAH (61%) or PAH associated with connective tissue diseases (23%) Adcirca, Alyq, or generic equivalent only: Lower dose or reduced dosing frequency may be required in elderly because of decreased renal or hepatic clearance Allow 48h after last tadalafil dose before nitrate administration.
- Cialis Weekend Pill allows flexible planning for intimacy.
- It can be used with or without food.
- Do not take with high-fat meals, as absorption slows.
- It’s a long-lasting solution for erectile issues.
- Effects start within 30-60 minutes.
- The pill’s duration covers an entire weekend.
- Cialis is available by prescription or online.
- Some prefer Cialis over daily ED medications.
- It’s not suitable for men with certain health conditions.
- Avoid grapefruit juice while taking Cialis.
- Be aware of potential drug interactions.
Allow 48h after last tadalafil dose before nitrate administration. nitroglycerin rectaltadalafil increases effects of nitroglycerin rectal by additive vasodilation. Use of nitroglycerin within a few days of PDE5 inhibitors is contraindicated. PDE5 inhibitors have been shown to potentiate the hypotensive effects of organic nitrates. tadalafil increases effects of nitroglycerin cialis super aktiv rectal by additive vasodilation. Either increases effects of the other by additive vasodilation.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Cialis Professional | 40mg | 90 + 2 Pills | 348.59€ 331.99€ | |
| Cialis Original | 20mg | 48 + 4 Pills | 224.69€ 213.99€ | |
| Cialis Professional | 20mg | 180 + 4 Pills | 423.11€ 402.96€ | |
| Cialis Generic | 5mg | 120 + 6 Pills | 132.92€ 126.59€ | |
| Cialis Soft Tabs | 20mg | 60 + 4 Pills | 159.37€ 151.78€ | |
| Cialis Super Active | 20mg | 10 Pills | 55.64€ 52.99€ | |
| Cialis Professional | 40mg | 120 + 4 Pills | 436.68€ 415.89€ | |
| Cialis Generic | 2.5mg | 180 + 10 Pills | 154.86€ 147.49€ | |
| Cialis Generic | 2.5mg | 120 + 6 Pills | 128.93€ 122.79€ | |
| Cialis Super Active | 20mg | 120 + 16 Pills | 382.15€ 363.95€ | |
| Cialis Generic | 20mg | 270 + 10 Pills | 335.21€ 319.25€ | |
| Cialis Generic | 5mg | 180 + 10 Pills | 159.65€ 152.05€ | |
| Cialis Generic | 20mg | 360 + 10 Pills | 427.34€ 406.99€ | |
| Cialis Original | 20mg | 22 + 2 Pills | 129.20€ 123.05€ |
Coadministration of PDE-5 inhibitors (eg, avanafil, sildenafil, tadalafil, vardenafil) and guanylate cyclase stimulators (eg, riociguat) is contraindicated due to risk of additive hypotension; do not administer 24 hr before or within 48hr of each other. Either increases effects of the other by pharmacodynamic synergism.
| Ingredient | Active Component | Dose per Pill | Inactive Fillers |
|---|---|---|---|
| Tadalafil | Yes | 20 mg | Lactose, Microcrystalline Cellulose |
| Microcrystalline Cellulose | No | N/A | Stabilizers |
| Hypromellose | No | N/A | Film Coating |
Coadministration of vericiguat with PDE-5 inhibitors may result in additive hypotensive effects. apalutamideapalutamide will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Coadministration of apalutamide, a strong CYP3A4 inducer, with drugs that are CYP3A4 substrates can result in lower exposure to these medications.
- Cialis Weekend Pill offers flexibility for users.
- It’s a preferred option for many men.
- Effects are influenced by age and health.
- The medication helps achieve and maintain erections.
- It’s important to communicate with your doctor.
- The pill is usually well-tolerated.
- It can boost confidence and reduce performance anxiety.
- Store in a secure, dry place away from children.
- Don’t take if allergic to tadalafil.
- Alcohol consumption can diminish effects.
- Use responsibly to prevent adverse effects.
Avoid or substitute another drug for these medications when possible. Evaluate for loss of therapeutic effect if medication must be coadministered.
| Country/Region | Average Price per Pack | Typical Pack Size | Purchase Methods |
|---|---|---|---|
| USA | $50 - $80 | 4-8 pills | Pharmacy, Online pharmacy |
| UK | £40 - £70 | 4-12 pills | Prescription, Online retailers |
| Canada | CAD 60 - 90 | 4-10 pills | Clinic, Online stores |
| Australia | AUD 70 - 130 | 4-8 pills | Pharmacist, Online shops |
Adjust dose according to prescribing information if needed. apalutamide will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. atazanaviratazanavir will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stop tadalafil >24 hours prior to protease inhibitor (PI) initiation, restart 7 days after PI initiation at 20 mg once daily, and increase to 40 mg once daily based on tolerability. atazanavir will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Tips to Get the Best Results from Cialis
4.6* from over 33,000 people like you. BSc (Hons) MBBS MRCGP AFHEA MA (Hons) AFMCP Answer a few simple questions to get the treatment you need. Indicated for treatment of erectile dysfunction (ED) Cialis (or generic equivalent) or Chewtadzy only PRN use: 10 mg PO initially before sexual activity, with or without food; may be increased to 20 mg or reduced to 5 mg on basis of efficacy and tolerability; in most patients, maximum dosing frequency is once daily Once-daily use (Cialis): 2.5 mg/day PO in single daily dose, without regard to timing of sexual activity, with or without food; may be increased to 5 mg/day on basis of efficacy and tolerability Indicated for treatment of signs and symptoms of benign prostatic hyperplasia (BPH); daily use also indicated for treatment of patients with both BPH and erectile dysfunction Cialis (or generic equivalent) or Chewtadzy only BPH with ED: 5 mg PO once daily, taken at approximately same time each day without regard to timing of sexual activity Coadministration with finasteride for BPH: Tadalafil 5 mg plus finasteride 5 mg PO once daily for ≤26 weeks; incremental benefit of tadalafil decreases from 4 weeks until 26 weeks, and the benefit beyond 26 weeks is unknown Indicated for pulmonary arterial hypertension (PAH) (WHO Group 1) to improve exercise ability; studies establishing effectiveness included predominately patients with NYHA Functional Class II – III symptoms and etiologies of idiopathic or heritable PAH (61%) or PAH associated with connective tissue diseases (23%) Adcirca, Alyq, Tadliq, or generic equivalent only 40 mg PO once daily; dividing dose for more frequent dosing is not recommended Patients also taking ritonavir: 20 mg PO once daily initially for ≥1 week; may be increased to 40 mg/day on basis of tolerability Cialis, Chewtadzy (PRN use)Mild (CrCl >50 mL/min): No dosage adjustment neededModerate (CrCl 30-50 mL/min): Not to exceed 5 mg PO once daily initially; maximum dosage, 10 mg PO q48hrSevere (CrCl <30 mL/min and on hemodialysis): Not to exceed 5 mg PO q72hr Mild (CrCl >50 mL/min): No dosage adjustment needed Moderate (CrCl 30-50 mL/min): Not to exceed 5 mg PO once daily initially; maximum dosage, 10 mg PO q48hr Severe (CrCl <30 mL/min and on hemodialysis): Not to exceed 5 mg PO q72hr Cialis (once daily use)ED (CrCl >50 mL/min): No dosage adjustment neededBPH or BPH/ED (CrCl 30-50 mL/min): 2.5 mg/day starting dose recommended; may increase to 5 mg according to individual responseED or BPH (CrCl <30 mL/min or hemodialysis): Not recommended ED (CrCl >50 mL/min): No dosage adjustment needed BPH or BPH/ED (CrCl 30-50 mL/min): 2.5 mg/day starting dose recommended; may increase to 5 mg according to individual response ED or BPH (CrCl <30 mL/min or hemodialysis): Not recommended Chewtadzy (once daily use)BPH, ED/BPHCrCl >50 mL/min: No dosage adjustment neededCrCl ≤50 mL/min or hemodialysis: Not recommended CrCl >50 mL/min: No dosage adjustment needed CrCl ≤50 mL/min or hemodialysis: Not recommended Adcirca, Alyq, TadliqMild-to-moderate (CrCl 31-80 mL/min): 20 mg PO once daily initially; may be increased to 40 mg once daily on basis of tolerabilitySevere (CrCl <30 mL/min and on hemodialysis): Avoid use Mild-to-moderate (CrCl 31-80 mL/min): 20 mg PO once daily initially; may be increased to 40 mg once daily on basis of tolerability Severe (CrCl <30 mL/min and on hemodialysis): Avoid use Cialis, Chewtadzy (PRN use)Mild-to-moderate (Child-Pugh class A or B): Not to exceed 10 mg PO once dailySevere (Child-Pugh class C): Not recommended Mild-to-moderate (Child-Pugh class A or B): Not to exceed 10 mg PO once daily Severe (Child-Pugh class C): Not recommended Cialis, Chewtadzy (once daily use)Mild-to-moderate (Child-Pugh class A or B): Data limited; caution advisedSevere (Child-Pugh class C): Not recommended Mild-to-moderate (Child-Pugh class A or B): Data limited; caution advised Severe (Child-Pugh class C): Not recommended Adcirca, Alyq, TadliqMild-to-moderate (Child-Pugh class A or B): Consider starting dosage of 20 mg PO once dailySevere (Child-Pugh class C): Avoid use Mild-to-moderate (Child-Pugh class A or B): Consider starting dosage of 20 mg PO once daily Severe (Child-Pugh class C): Avoid use ED PRN use: Not to exceed 10 mg/72 hr ED or ED/BPH once-daily use: Not to exceed 2.5 mg/day Adcirca, Alyq, TadliqOn ritonavir for at least 1 week: Start tadalafil at 20 mg PO qDay; may increase to 40 qDay based on individual tolerabilityAvoid tadalafil during ritonavir initiationStop tadalafil at least 24 hr before to starting ritonavirAfter at least 1 week following ritonavir initiation, resume tadalafil 20 mg PO qDay; may increase to 40 qDay based on individual tolerability On ritonavir for at least 1 week: Start tadalafil at 20 mg PO qDay; may increase to 40 qDay based on individual tolerability Stop tadalafil at least 24 hr before to starting ritonavir After at least 1 week following ritonavir initiation, resume tadalafil 20 mg PO qDay; may increase to 40 qDay based on individual tolerability Chewtadzy: Not indicated for once daily use for ED because dosing is not possible (recommended dosage for this indication cannot be achieved with lowest available strength) Orphan designation for Duchenne muscular dystrophy (DMD) Eli Lilly and Company; Lilly Corporate Center; Indianapolis, IN 46285 Indicated for treatment of erectile dysfunction (ED) Cialis or generic equivalent only: No dosage adjustment is warranted solely on basis of age; however, greater sensitivity to medications in some older individuals should be considered Indicated for pulmonary arterial hypertension (PAH) (WHO Group 1) to improve exercise ability; studies establishing effectiveness included predominately patients with NYHA Functional Class II – III symptoms and etiologies of idiopathic or heritable PAH (61%) or PAH associated with connective tissue diseases (23%) Adcirca, Alyq, or generic equivalent only: Lower dose or reduced dosing frequency may be required in elderly because of decreased renal or hepatic clearance Allow 48h after last tadalafil dose before nitrate administration. Allow 48h after last tadalafil dose before nitrate administration. nitroglycerin rectaltadalafil increases effects of nitroglycerin rectal by additive vasodilation.
Cialis form
Use of nitroglycerin within a few days of PDE5 inhibitors is contraindicated. PDE5 inhibitors have been shown to potentiate the hypotensive effects of organic nitrates. tadalafil increases effects of nitroglycerin cialis super aktiv rectal by additive vasodilation. Either increases effects of the other by additive vasodilation. Coadministration of PDE-5 inhibitors (eg, avanafil, sildenafil, tadalafil, vardenafil) and guanylate cyclase stimulators (eg, riociguat) is contraindicated due to risk of additive hypotension; do not administer 24 hr before or within 48hr of each other. ceritinibceritinib will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. ceritinib will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. clarithromycinclarithromycin will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. For ED limit tadalafil to max of 2.5 mg/day (for daily use) or 10 mg dose every 72 hr (for use as needed).
STRONGER ERECTIONS, BETTER SEX
atazanavir will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. ceritinibceritinib will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. ceritinib will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. clarithromycinclarithromycin will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. For ED limit tadalafil to max of 2.5 mg/day (for daily use) or 10 mg dose every 72 hr (for use as needed).
If I take 5 milligrams (mg) of Cialis daily, how long does it take the drug to work?
Avoid concurrent use of tadalafil for pulmonary HTN in patients taking strong CYP3A4 inhibitors. clarithromycin will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. cobicistatcobicistat will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Adjust tadalafil dose for PAH; if on cobicistat, start tadalafil 20 mg/day and may increase up to 40 mg/day; avoid tadalafil when starting cobicistat; for ED, may take a single dose of tadalafil not exceeding 10 mg in 72 hr. Avoid concurrent use of tadalafil for pulmonary HTN in patients taking strong CYP3A4 inhibitors. clarithromycin will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. cobicistatcobicistat will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Adjust tadalafil dose for PAH; if on cobicistat, start tadalafil 20 mg/day and may increase up to 40 mg/day; avoid tadalafil when starting cobicistat; for ED, may take a single dose of tadalafil not exceeding 10 mg in 72 hr.
How should this medicine be used?
We ship every order in plain, discreet packaging, without any branding or labels. You don’t need health insurance or an existing prescription to use our service. Our clinicians will issue a free private prescription if you’re eligible for treatment. After you’ve filled out the online consultation, you’ll be able to choose from recommended treatments for erectile dysfunction.You’ll have the option to make a one-time purchase, or start a subscription.If you subscribe we’ll automatically refill your treatment so you don’t run out, without the need to regularly complete a consultation or checkout. You can cancel subscription online at anytime.
Priapism and Your Cialis Dose
Order in6 hrs 4 minsfor delivery by tomorrow All content on this page has been medically reviewed by: Hassan Thwaini, Clinical Pharmacist and Copywriter, Master of Pharmacy (MPharm) on 30 March, 2026. Tadalafil is a clinically-proven erectile dysfunction treatment that gives you the freedom to enjoy sex when you want it. It lasts for 36 hours - so there’s less need for planning before sex. Find the clinically proven ED treatment that suits you best. No names, no logos, no delivery fee.