Dapoxetine for the Treatment of Premature Ejaculation: Results from a Randomized, Double-Blind, Placebo-Controlled Phase 3 Trial in 22 Countries

We also offer prevention of vaginitis through phone consultation and medication delivery.

Priligy Alternatives: Other Options for Premature Ejaculation

Prescriptions from facilities that do not conduct various tests, or personal imports without testing, carry the significant risk of HIV resistance and worsening of hepatitis B. – 1 bottle of PrEP (30 tablets), Descovy – Syphilis test (results notified via e-mail) – Renal function test (results notified via e-mail) – 3 bottles of PrEP (90 tablets), Descovy – Syphilis test (results notified via e-mail) – Renal function test (results notified via e-mail) – 6 bottles of PrEP (180 tablets), Descovy – Syphilis test (results notified via e-mail) – Renal function test (results notified via e-mail) – Extra test kit to use 3 months after (HIV, hepatitis B, syphilis and renal function) If you underwent HIV and hepatitis B testing within the past week, we can prescribe PrEP at the prices below. Please bring documentation of your test results. You must undergo appropriate testing before initiating or continuing PrEP. Obtaining PrEP from facilities that do not perform the required tests, or through personal imports without testing, carries serious risks including HIV resistance and worsening hepatitis B.

Molecular Weight

Tests conducted outside our clinic also qualify. If you use our three-exam regular package, it already includes HIV and hepatitis B tests, so you may receive your prescription on the day of testing. Available only to those who bring HIV and hepatitis B test results from within the past week – Renal function test (email results): additional 500 JPY upon request Available only to those who bring HIV and hepatitis B test results from within the past week – Renal function test (email results): additional 500 JPY upon request For those who import PrEP on their own, we have a package of routine check-ups. for those importing PrEP on their own – Syphilis test (results notified via e-mail) – Renal function test (results notified via e-mail) Gonorrhea and Chlamydia (genitals, throat, anus): 3,000 JPY (20,000 JPY) Discharge test (vaginal candida, vaginal trichomonas and bacterial vaginosis): 3,000 JPY (4,500 JPY) Contraceptive injection (Depo-Provera): 8,000 JPY* (9,000 JPY) per dose or 22,000 JPY* (25,000 JPY) per 3-dose package *If you purchase PrEP, doxy-PEP or medication for the prevention of vaginal candida from us, we can offer special pricing. For patients using PrEP who wish to start Doxy-PEP, same-day prescription is available by adding the gonorrhea and chlamydia test (genital, throat and rectal). When it recurs four or more times per year, it is referred to as recurrent vaginal candida, and recurrence rates of approximately 60-70% within 6 months have been reported.

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Using preventive medication for vaginal candida taken once weekly for 6 months has been reported to reduce the recurrence rate to approximately 10-20%.

PEP (HIV Post-Exposure Prophilaxis)

We are accumulating data to evaluate the effectiveness of Doxy-PEP in Japan and aim to develop new preventive healthcare models and contribute to society. [Price] = [Consultation Fee] + [Package Price] + [Optional Fees] – Consultation Fee: First visit 2,500 JPY, Follow-up 1,000 JPY – Doxy-PEP prescriptions require a mandatory consultation with a doctor. Before starting or continuing Doxy-PEP, proper testing is essential. Receiving a prescription without testing or through personal imports without examination increases the risk of antimicrobial resistance and is dangerous. To receive a Doxy-PEP prescription, testing for syphilis, gonorrhea and chlamydia (all potentially exposed sites) is required.

Neurocognitive safety

We offer special discounted STI testing for everyone starting or continuing Doxy-PEP. Syphilis, gonorrhea and chlamydia (genital, throat and rectum): 5,000 JPY (normally 20,000 JPY) If you prefer individual tests in combination with other services, we offer the following discounted prices: Syphilis (quantitative): 3,000 JPY (normally 5,000 JPY) Gonorrhea and chlamydia (genital, throat and rectum): 3,000 JPY (normally 20,000 JPY) If you have completed testing for syphilis, tadalafil dapoxetine gonorrhea and chlamydia (all potentially exposed sites) within the past week, you can receive a prescription with only a consultation and medication fee. This applies to test results from other clinics as well. If you are using our 3-test regular package, Doxy-PEP can be prescribed on the day of testing, as it includes syphilis, gonorrhea and chlamydia. If you are requesting Doxy-PEP as a medication-only option, please bring documentation of your test results. Induction therapy (initial phase): Oral dosing on day 1, day 4 and day 7 (3 doses total) Maintenance therapy (maintenance phase): As a general rule, continue oral dosing once weekly for 6 months After completing 6 months of maintenance therapy, we will monitor progress and consider next steps as needed.

• Dapoxetine is designed specifically for men with PE.
• Over-the-counter sales increase the risk of misuse.
• Some online platforms may sell banned drugs illegally.
• Personal health history should guide dapoxetine use.
• Pharmacovigilance ensures medication safety.
• Consider counseling along with medication for better results.
• Check expiration date before use.
• Keep medication in a cool, dry place.
• Report any adverse reactions to health authorities.
• Be aware of regional laws regarding dapoxetine sales.

If you experience side effects such as mild nausea or abdominal discomfort, or if you are planning pregnancy, the duration can be adjusted in consultation with a doctor.

How does Priligy (dapoxetine) work for premature ejaculation?

Always undergo proper testing when starting or continuing Doxy-PEP. Prescriptions from clinics that do not offer testing or imported medications without testing are risky and may lead to antimicrobial resistance. We also offer a discounted vaginal discharge test (for vaginal candida, trichomonas and bacterial vaginosis) for those prescribed Doxy-PEP. Vaginal discharge test (vaginal candida, trichomonas, bacterial vaginosis): 3,000 JPY (normally 4,500 JPY) Contraceptive injection (Depo-Provera): 8,000 JPY* (9,000 JPY) per dose or 22,000 JPY* (25,000 JPY) per 3-dose package *If you purchase PrEP, doxy-PEP or medication for the prevention of vaginal candida from us, we can offer special pricing. Vaginitis (vaginal candida and bacterial vaginosis) can be managed with an option focused on preventing recurrence. For first-time patients, the induction plus 6-month continuation package offers the best value.

• Dapoxetine is a fast-acting medication for PE.
• Its OTC status is controversial and varies by region.
• Always check for genuine product authenticity.
• Read reviews before purchasing OTC dapoxetine.
• Beware of fake or expired medications sold online.
• Overuse can cause adverse serotonin effects.
• Natural alternatives are also popular.
• Discuss any health conditions with a doctor first.
• Dapoxetine should be used as part of a broader treatment plan.
• Be cautious with online sources claiming OTC availability.

For ongoing therapy, you may choose a 1-month, 3-month or 6-month supply. Induction package (day 1, 4 and 7): 4,000 JPY Continuation 1 month (once weekly x 4): 5,000 JPY Continuation 3 months (once weekly x 12): 12,000 JPY Continuation 6 months (once weekly x 24): 20,000 JPY Induction plus continuation 6-month package: 22,000 JPY For patients starting or undergoing induction with preventive medication for vaginal candida, we offer vaginal discharge testing and contraceptive injections at special prices.

Dosage (mg)	Typical Usage Frequency	Recommended Maximum Dose	Common Side Effects
30	Once daily	60 mg/day	Nausea, headache
60	Once daily	60 mg/day	Dizziness, dry mouth
30-60	As needed (pre-intimate)	60 mg per occasion	Insomnia, diarrhea

Vaginal discharge test (vaginal candida, trichomonas and bacterial vaginosis): 3,000 JPY (4,500 JPY) Contraceptive injection (Depo-Provera): 8,000 JPY (9,000 JPY) per dose or 22,000 JPY (25,000 JPY) for 3 doses Special pricing is available for those who purchase PrEP, doxy-PEP or preventive medication for vaginal candida from us.

• Dapoxetine's patent and approval status impacts OTC legality.
• Some clinics offer guided use without full prescription.
• OTC availability influences self-medication trends.
• Dapoxetine price may fluctuate based on source.
• Use the medication exactly as directed.
• Avoid combining dapoxetine with other SSRIs or medications.
• Users should monitor their response and side effects.
• Inform healthcare professionals about all medications taken.
• Dapoxetine is generally well-tolerated when used correctly.
• Always seek medical advice for persistent issues.

Bacterial vaginosis occurs when the balance of bacteria in the vagina is disrupted.

Medication Class	Common Drugs	Interaction Notes	Risk Level
Monoamine Oxidase Inhibitors (MAOIs)	Phenelzine, Tranylcypromine	Severe serotonin syndrome risk	High
Other SSRIs	Sertraline, Fluoxetine	Increased risk of serotonin syndrome	Moderate to high
Blood Pressure Medications	Beta-blockers	Possible hypotensive effect	Low to moderate

It can develop even in individuals without sexual experience, and many women may experience it at least once.

Acne treatment and prevention

This option also offers a 2,000 JPY discount compared to the standard price. We offer a comprehensive package that includes mental support for those taking PEP all the way until HIV negativity is confirmed. Depending on the circumstances of the potential exposure, necessary additional tests are also provided within this package at no extra cost. For urgent PEP prescriptions, such as when more than 72 hours have passed since exposure which is beyond the usual consultation hours, please contact us via our official LINE account. [Price] = [Consultation Fee] + [Package Price] + [Optional Fees] – Consultation Fee: First visit 2,500 JPY, Follow-up 1,000 JPY – A doctor’s consultation is required for PrEP prescriptions.

CAS registry number (Chemical Abstracts Service)

– 1 bottle of PEP (30 tablets of Taffic) * Take 1 tablet daily for 28 days. The remaining 2 tablets are for backup use. Special discounted testing for syphilis, gonorrhea, chlamydia, and other STIs is available at the start and after completing PEP. We offer the following discounted tests exclusively to those who purchase a PEP package, valid for one month from the date of purchase. Gonorrhea & Chlamydia (Genital, Throat, Anal – 3 sites): 3,000 JPY (20,000 JPY) Vaginal Discharge Test (Vaginal Candida, Trichomonas, Bacterial Vaginosis): 3,000 JPY (4,500 JPY) These options are valid for one month after purchasing PEP. While it usually does not cause severe symptoms, it may increase the risk of HIV infection and other STIs.

How to Get the Most From Dapoxetine?

A follow-up test one month dapoxetine 60 mg buy online after completing PEP is available at a special discounted price. If you wish to use doxy-PEP in addition to PEP, adding the “Gonorrhea and chlamydia (genital, throat and rectum; 3 sites)” test (3,000 JPY) allows same-day doxy-PEP prescription. We offer gonorrhea, chlamydia and syphilis testing at a special price for everyone who starts or continues doxy-PEP. HIV, Hepatitis B & Kidney function: 3,000 JPY HIV, Hepatitis B, Kidney function & Syphilis: 5,000 JPY This method involves taking medication within 72 hours after sexual activity to prevent syphilis, gonorrhea, and chlamydia. The reported effectiveness of prevention is 87% for syphilis, 88% for chlamydia, and 55% for gonorrhea (International AIDS Society, July 2022).

Short Duration

These STIs have a high transmission rate when having sexual contact with an infected person—around 30% for syphilis and 50% for chlamydia and gonorrhea—making this prevention method highly effective and globally recognized. We provide thorough explanations of the risks and benefits of preventive medications during a doctor’s consultation and determine eligibility for each patient. Please consult with our doctor for more details. Prescriptions can also be provided through telephone consultations. In collaboration with the AIDS Clinical Center (ACC) and our partner clinic, Personal Health Clinic based in Tokyo, we prescribe Doxy-PEP to patients at high risk of contracting STIs. It is known that treating partners together can help prevent bacterial vaginosis. A randomized controlled trial published in March 2025 reported that, in addition to standard treatment for women, providing male partners with 7 days of oral medication plus topical treatment reduced the 12-week recurrence rate from 63% to 35%, approximately a 50% reduction.

• Only a licensed healthcare provider can determine the appropriate treatment.
• Illegally imported dapoxetine may have incorrect storage conditions, affecting potency.
• Some men may experience fainting (syncope) with dapoxetine, requiring caution.
• Official medication guides detail all potential side effects and instructions.
• Stress and anxiety can contribute to PE; addressing these may be beneficial.
• Support groups can provide shared experiences and coping strategies.